David A Sinclair Selected Research

Metabolic Syndrome (Dysmetabolic Syndrome X)

1/2018	Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.
4/2013	Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.

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David A Sinclair Research Topics

Disease

11	Insulin Resistance 07/2023 - 11/2006
9	Inflammation (Inflammations) 10/2023 - 08/2008
8	Neoplasms (Cancer) 01/2017 - 11/2002
7	Type 2 Diabetes Mellitus (MODY) 01/2022 - 11/2007
7	Obesity 01/2022 - 09/2011
6	Genomic Instability 01/2016 - 11/2002
4	Frailty 01/2022 - 01/2019
3	Body Weight (Weight, Body) 12/2023 - 10/2020
3	Fibrosis (Cirrhosis) 01/2022 - 12/2010
3	Ischemia 07/2020 - 10/2013
3	Cardiovascular Diseases (Cardiovascular Disease) 11/2019 - 12/2015
3	Metabolic Diseases (Metabolic Disease) 01/2018 - 04/2013
3	Cardiomyopathies (Cardiomyopathy) 01/2018 - 04/2013
3	Hypoxia (Hypoxemia) 01/2018 - 10/2013
3	Mitochondrial Diseases (Mitochondrial Disease) 10/2016 - 12/2010
3	Carcinogenesis 01/2014 - 04/2008
2	Progeria (Hutchinson Gilford Syndrome) 11/2023 - 12/2019
2	HIV Infections (HIV Infection) 01/2022 - 11/2019
2	COVID-19 01/2022 - 01/2020
2	Reperfusion Injury 07/2020 - 01/2018
2	Maternal Obesity 01/2019 - 11/2017
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 07/2007
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2018 - 04/2013
2	Disease Resistance 11/2016 - 06/2009
2	Alzheimer Disease (Alzheimer's Disease) 01/2014 - 07/2007
1	Wounds and Injuries (Trauma) 12/2023
1	Glaucoma 12/2023
1	Overweight 07/2023
1	Virus Diseases (Viral Diseases) 01/2022
1	Weight Loss (Weight Reduction) 01/2022
1	Coinfection 01/2022
1	Retinal Detachment (Retinal Detachments) 12/2020
1	Kyphosis 12/2019
1	Alopecia (Baldness) 12/2019
1	Premature Aging 12/2019
1	Renal Insufficiency (Renal Failure) 11/2019
1	Bone Fractures (Bone Fracture) 11/2019
1	Hypertension (High Blood Pressure) 11/2019
1	Infections 11/2019
1	Nervous System Diseases (Neurological Disorders) 10/2019
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2019
1	Starvation 01/2018
1	Dyslipidemias (Dyslipidemia) 01/2018
1	Hyperemia 11/2017
1	Breast Neoplasms (Breast Cancer) 01/2017
1	Hyperplasia 01/2016
1	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 12/2015

Drug/Important Bio-Agent (IBA)

19	Sirtuin 1IBA 01/2018 - 11/2002
18	NAD (NADH)IBA 07/2023 - 11/2002
11	SirtuinsIBA 01/2022 - 06/2006
9	ResveratrolIBA 11/2017 - 11/2006
8	Proteins (Proteins, Gene)FDA Link 11/2023 - 11/2002
5	Nicotinamide MononucleotideIBA 07/2023 - 11/2017
5	Sirtuin 3IBA 01/2023 - 12/2010
4	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 11/2007
3	CholesterolIBA 07/2023 - 01/2013
3	Insulin (Novolin)FDA Link 03/2013 - 11/2006
2	Retinaldehyde (Retinal)IBA 12/2023 - 10/2013
2	Sirtuin 2IBA 11/2023 - 02/2015
2	LDL Lipoproteins (beta Lipoproteins)IBA 07/2023 - 01/2013
2	LDL CholesterolIBA 07/2023 - 01/2015
2	LipidsIBA 07/2023 - 11/2017
2	Antiviral Agents (Antivirals)IBA 01/2022 - 01/2020
2	EnzymesIBA 01/2022 - 01/2014
2	SRT1720IBA 10/2020 - 03/2014
2	SRT2104IBA 11/2016 - 10/2014
2	SRT3025IBA 07/2015 - 01/2015
2	Lysine (L-Lysine)FDA Link 01/2014 - 12/2010
2	AMP-Activated Protein KinasesIBA 01/2013 - 11/2006
2	Histone Deacetylases (Histone Deacetylase)IBA 11/2008 - 11/2002
2	ChromatinIBA 11/2008 - 09/2003
1	TabletsIBA 07/2023
1	oxidized low density lipoproteinIBA 07/2023
1	lipoprotein cholesterolIBA 07/2023
1	HDL CholesterolIBA 07/2023
1	HLA Antigens (Human Leukocyte Antigens)IBA 01/2022
1	Indicators and Reagents (Reagents)IBA 09/2021
1	Neuroprotective AgentsIBA 12/2020
1	Adenylyl Cyclases (Adenylyl Cyclase)IBA 07/2020
1	Mitochondrial DNA (mtDNA)IBA 12/2019
1	Biomarkers (Surrogate Marker)IBA 01/2019
1	Protein Isoforms (Isoforms)IBA 01/2018
1	GlycogenIBA 01/2018
1	Transcription Factors (Transcription Factor)IBA 01/2018
1	Phosphates (Orthophosphate)IBA 01/2018
1	Amino Acids FDA Link 01/2018
1	Sulfur Amino AcidsIBA 01/2018
1	Oxygen (Dioxygen)IBA 01/2018
1	PentosesIBA 01/2018
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018
1	C-PeptideIBA 11/2017
1	Triglycerides (Triacylglycerol)IBA 11/2017
1	Citrate (si)-Synthase (Synthase, Citrate)IBA 11/2017
1	Poly Adenosine Diphosphate RiboseIBA 01/2017
1	Floxuridine (FUdR)FDA LinkGeneric 03/2016

Therapy/Procedure

5	Therapeutics 12/2023 - 11/2007
1	Rejuvenation 10/2023
1	Deprescriptions 01/2022
1	Polypharmacy 11/2019
1	Caloric Restriction 12/2015